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| DIAGNOSIS OF CYTOMEGALOVIRUS INFECTION IN BABY |
Cytomegalovirus infection in pregnancy can cause serious disease in baby in utero & infants. 1-3% of women are infected during pregnancy & in 1 out of every 2 cases, the infection is passed on to the fetus & causes malformation. In immunocompromised patients CMV infection can be still more severe. |
Detection of CMV specific Igm is an essential tool for diagnosis & follow up of acute infection, A rise in anti-CMV IGM titre may be indicative of recent infection. Primary infection only causes disease & malformation in baby. |
For differentiation of primary infection as opposed to reactivation, ie chronic infection is the solution. It can be detected by CMV Igm avidity test. |
Igm avidity testing is recommended to differentiate between primary infection & reactivation. Thus a positive Igm & low avidity suggest primary, or recent infection. Whereas a high avidity Igm indicates either Igm persistence or reactivation (chronic infection) |
| For example Mrs.Beena had |
- CMV Igm POSITIVE
- CMV-AVIDITY TEST, 0.89 <0.2 INDEX : LOW AVIDIT
(RECENT INFECTION)
0 0.2 - <0.8 BORDERLINE AVIDITY
0 0.8 INDEX : HIGH AVIDITY
(REACTIVATION/CHANGES INFACTION)
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| This shows child will be free of CMV infection |
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| Last 1000 High Risk Births Ananlysed Antenatal Care at Life Care Centre |
Delivery: Pushpanjali Medical Centre , Max Balaji Hospital (2008 Dec) |
| Singletons |
Twins |
Mean gestational – 39 Weeks
Age (Weeks) |
35.7 |
% Very Preterm – 1.7
(<33 weeks) |
16 |
Preterm (<37 weeks) – 9.43 |
50.9 |
Mean birth weight – 3.06 |
2.3 |
% Very low birth weight – 1.1
(<1500) |
10.1 |
% Low Birth weight (2500 gm) – 6.00% |
72.24 |
% LSCS – 42% |
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% PIH – 27%
Hellp Syndrome – 0.3% |
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Anaemia – at Ist Visit – 58%
at delivery – 27% |
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PPH - 4% |
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| Condition for Cesarean Section |
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